WILLIAM H. CROSBY
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Paroxysmal nocturnal hemoglobinuria (PNH) is an uncommon disease, but not so rare as has been supposed. At least 164 case reports have appeared in print, 28 of them since January, 1950.† PNH is manifested by a chronic hemolytic disease that becomes more active when the patient sleeps. During a hemolytic crisis of moderate intensity the destruction of red cells during sleep may result in "nocturnal" hemoglobinuria that disappears shortly after the patient has been awake for several hours. During severe crises hemoglobinuria may persist day and night. In the absence of crises the patient with PNH may live for years
CROSBY WH. PAROXYSMAL NOCTURNAL HEMOGLOBINURIA: REPORT OF A CASE COMPLICATED BY AN AREGENERATIVE (APLASTIC) CRISIS*. Ann Intern Med. 1953;39:1107–1117. doi: https://doi.org/10.7326/0003-4819-39-5-1107
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Published: Ann Intern Med. 1953;39(5):1107-1117.
Hematology/Oncology, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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