THOMAS N. JAMES, M.D.; RAYMOND W. MONTO, M.D., F.A.C.P.; JOHN W. REBUCK, M.D.
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During the course of multiple myeloma most patients exhibit a tendency to bleed. Although it may be an early manifestation, the incidence of abnormal bleeding is greater in the more advanced phases. The severity of bleeding varies from petechiae to exsanguination.1 Despite wide recognition of this feature of myeloma, its pathogenesis has remained obscure. The etiologic factors most often suggested have been (1) the presence of abnormal plasma proteins impairing normal coagulation,2, 3, 4, 5 and (2) deficient clot retraction, of unstated cause.2, 3 That the platelet count in myeloma is usually normal has been repeatedly stated by Custer,6 Limarzi,2
JAMES TN, MONTO RW, REBUCK JW. THROMBOCYTOPENIA AND ABNORMAL BLEEDING IN MULTIPLE MYELOMA*. Ann Intern Med. 1953;39:1281–1287. doi: https://doi.org/10.7326/0003-4819-39-6-1281
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Published: Ann Intern Med. 1953;39(6):1281-1287.
Hematology/Oncology, Multiple Myeloma, Platelet Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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