GLENN H. RICHMOND; GRANT D. BEARDSLEY
Since the first clinical use of nitrogen mustard compounds in 1942,1 hundreds of articles have appeared in the medical literature to attest its value in the palliative therapy of Hodgkin's disease, lymphosarcoma, chronic leukemia and other neoplastic diseases. The narrow margin between the toxic and the therapeutic dose is shown by the occurrence of toxicity in almost every case treated effectively. It has been generally accepted that toxicity is a necessary accompaniment of effective therapy, and the literature on this subject has been limited. The pharmacologic activities of the nitrogen and sulfur mustards have been excellently presented by Gilman and
RICHMOND GH, BEARDSLEY GD. NITROGEN MUSTARD THERAPY COMPLICATED BY ACUTE RENAL FAILURE DUE TO URIC ACID CRYSTALLIZATION1. Ann Intern Med. ;39:1327–1332. doi: 10.7326/0003-4819-39-6-1327
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Published: Ann Intern Med. 1953;39(6):1327-1332.
Acute Kidney Injury, Nephrology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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