WILLIAM H. BEIERWALTES, M.D., F.A.C.P.
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Almost 100 patients with localized pretibial myxedema had been reported by 1949.1 The association of these lesions with exophthalmic goiter has been noted as early as 1930.2 Curtis, Cawley and Johnwick3 in 1949 reported the association of malignant exophthalmos and pretibial myxedema in three cases studied by them and in seven others known or reported previously. These authors also first emphasized3 that both the malignant exophthalmos and the localized myxedema might be due to the same factor, i.e., a local effect of thyroid-stimulating hormone, T.S.H., in the extraocular tissues and in the subcutaneous areas of the anterior lower leg. Review
BEIERWALTES WH. CLINICAL CORRELATION OF PRETIBIAL MYXEDEMA WITH MALIGNANT EXOPHTHALMOS*. Ann Intern Med. 1954;40:968–984. doi: https://doi.org/10.7326/0003-4819-40-5-968
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Published: Ann Intern Med. 1954;40(5):968-984.
Endocrine and Metabolism, Thyroid Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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