BEN ROTHFELD, M.D.; J. M. RODAS, M.D.
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The syndrome of panhypopituitarism was first clearly defined in 1914 by Simmonds.1 He felt that the pathogenesis of this disease post partum was due to the embolic occlusion of the arterial blood supply, with resultant ischemic necrosis of the pituitary. That this was not the true pathogenesis was shown by Sheehan in a series of papers.2-4 In these papers he proved that the etiology in cases developing post partum was that the blood supply of the gland after delivery is normally reduced rapidly. If further reduced by circulatory collapse the blood flow may reach an extremely low level. Thrombosis
ROTHFELD B, RODAS JM. DIABETES AND PANHYPOPITUITARISM1. Ann Intern Med. 1954;41:140–146. doi: 10.7326/0003-4819-41-1-140
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Published: Ann Intern Med. 1954;41(1):140-146.
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