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Original Research |1 August 1954

ULCERATIVE COLITIS: THERAPEUTIC EFFECTS OF CORTICOTROPIN (ACTH) AND CORTISONE IN 120 PATIENTS12

JOSEPH B. KIRSNER, M.D., Ph.D., F.A.C.P.; WALTER L. PALMER, M.D., Ph.D., F.A.C.P.

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Abstract

INTRODUCTION

The effects of corticotropin (ACTH) and cortisone in ulcerative colitis have been characterized as beneficial,1-5 indifferent6-8 and unfavorable.9-14 Numerous studies also have emphasized the complications of therapy and the recurrences.15-20 The observation of 40 patients in 19511 indicated that, while ACTH and cortisone do not cure ulcerative colitis, they may be useful adjuncts, initiating rapid and occasionally dramatic clinical improvement. The present report summarizes our experience with corticotropin and cortisone in 120 patients with ulcerative colitis observed during the past four years.

PATIENTS STUDIED

General Data: The series includes 65 females and 55 males; the majority were between 20

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KIRSNER JB, PALMER WL. ULCERATIVE COLITIS: THERAPEUTIC EFFECTS OF CORTICOTROPIN (ACTH) AND CORTISONE IN 120 PATIENTS12. Ann Intern Med. 1954;41:232–250. doi: 10.7326/0003-4819-41-2-232

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Published: Ann Intern Med. 1954;41(2):232-250.

DOI: 10.7326/0003-4819-41-2-232

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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