DONALD D. VAN SLYKE
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The manner in which tubular injury can cause excretory failure was observed by A. N. Richards in 1929.1 He watched through a microscope the nephrons of frogs that had been poisoned with sublethal doses of mercuric chloride, bichromate and other nephrotoxic poisons. Blood circulation and filtration in the glomeruli went on at a normal rate, but the entire filtrate was reabsorbed in the tubules, with resultant anuria. Richards concluded: "The only explanation which I can reach is that, under these conditions, the osmotic pressure of the blood proteins is unobstructed by the normal qualities of the tubular epithelium and is
VAN SLYKE DD. RENAL TUBULAR FAILURE OF SHOCK AND NEPHRITIS1. Ann Intern Med. ;41:709–738. doi: 10.7326/0003-4819-41-4-709
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Published: Ann Intern Med. 1954;41(4):709-738.
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