MILTON S. SACKS, M.D.
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The unique importance of iron in mammalian physiology lies in its participation in intracellular respiration. Sixty to 70% of the body's iron is to be found in the respiratory pigment, hemoglobin. Although only minute amounts occur in the various cytochrome enzymes, here also the metal functions in respiratory processes. Iron exists in two states in the body, either chelated with a heme or porphyrin unit (as hemoglobin) or combined in a non-porphyrin form with a protein (table 1). In the latter group are included the storage forms of iron (ferritin, hemosiderin) and transport iron (iron-transferrin) in the circulating blood.1
SACKS MS. SOME ASPECTS OF IRON METABOLISM. Ann Intern Med. ;42:458–463. doi: 10.7326/0003-4819-42-2-458
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Published: Ann Intern Med. 1955;42(2):458-463.
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