WILLIAM J. MARTIN, M.D.; LAURENTIUS O. UNDERDAHL, M.D.; DON R. MATHIESON, M.D.; DAVID G. PUGH, M.D.
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From 1927 to 1953, inclusive, a period of 26 years, the diagnosis of alkaptonuria was made in only 12 cases at the Mayo Clinic. Moreover, the medical literature of the last 370 years contains only about 200 reports of cases.1 Three of the Mayo Clinic cases were reported in 1952.1 Preparation of this previous report prompted us to a more thorough investigation.
Following are brief reports of the relevant data in the 12 cases.
Case 1. Alkaptonuria was first recognized at the clinic in August, 1927. The patient was a white girl, 10½ years of age, whose chief
MARTIN WJ, UNDERDAHL LO, MATHIESON DR, PUGH DG. ALKAPTONURIA: REPORT OF 12 CASES1. Ann Intern Med. ;42:1052–1064. doi: 10.7326/0003-4819-42-5-1052
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Published: Ann Intern Med. 1955;42(5):1052-1064.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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