ROBERT D. GITTLER, M.D.; MILTON KISSIN, M.D., F.A.C.P.; JOSEPH LITWINS, M.D., F.A.C.P.
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The allergic and toxic manifestations which may follow the use of quinidine are well known.1 Such reactions may be classified as (1) gastrointestinal, (2) respiratory, (3) dermatologic, (4) renal, (5) neurologic, (6) hematopoietic, (7) febrile, and (8) combined forms. Gastrointestinal effects ascribed to quinidine are nausea, vomiting, abdominal distress and diarrhea; respiratory effects resemble a histamine reaction, with coryza and bronchospasm; dermatologic effects occur as pruritus, urticaria, angioneurotic edema, morbilliform, scarlatiniform and maculopapular rashes, exfoliative dermatitis, pigmentation, and eczematoid and pemphigoid lesions; renal effects are hematuria and albuminuria; cardiovascular toxic effects seen are ventricular fibrillation and asystole; hematopoietic effects include
GITTLER RD, KISSIN M, LITWINS J. QUINIDINE-INDUCED THROMBOCYTOPENIC PURPURA COMPLICATING DICUMAROL THERAPY1. Ann Intern Med. 1955;42:1118–1122. doi: 10.7326/0003-4819-42-5-1118
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Published: Ann Intern Med. 1955;42(5):1118-1122.
Cardiology, Coagulopathies, Hematology/Oncology, Platelet Disorders, Rhythm Disorders and Devices.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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