MARK H. LEPPER, M.D.
Ever since the introduction of antibiotics there has been considerable interest in the problems stemming from the resistance of certain species or strains of bacteria. Because of the experience with the sulfonamides before penicillin became available, many workers felt that the development of resistance would become a major problem in a short period of time, while others adopted a wait-and-see attitude. During the intervening years the picture has been complicated by (1) the observation that new infections caused by resistant organisms may be superimposed on preëxisting infections, and (2) the introduction of new antibiotics. However, it is now possible to
LEPPER MH. MICROBIAL RESISTANCE TO ANTIBIOTICS12. Ann Intern Med. ;43:299–315. doi: 10.7326/0003-4819-43-2-299
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Published: Ann Intern Med. 1955;43(2):299-315.
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