ELLARD M. YOW, M.D.
It is not difficult to understand the decreased interest in the sulfonamides following the introduction of penicillin, an agent which produced dramatic therapeutic results and which could be administered in unlimited amounts without evidence of toxicity. This came as an impressive relief after the trying years of carefully regulating the dose of the sulfonamides so as to maintain an effective level and yet remain within the relatively narrow margin between the toxic and therapeutic levels. Physicians were anxious to forget the difficulties encountered in the administration of large amounts of fluid and alkali, given in an attempt to prevent the
YOW EM. A REËVALUATION OF SULFONAMIDE THERAPY1. Ann Intern Med. 1955;43:323–332. doi: 10.7326/0003-4819-43-2-323
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Published: Ann Intern Med. 1955;43(2):323-332.
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