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Original Research |1 August 1955

SERUM GLUTAMIC OXALACETIC TRANSAMINASE ACTIVITY AS AN INDEX OF LIVER CELL INJURY: A PRELIMINARY REPORT*†

FELIX WRÓBLEWSKI, M.D.; JOHN S. LADUE, M.D., Ph.D., F.A.C.P.

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Abstract

INTRODUCTION

Glutamic oxalacetic transaminase is widely distributed in animal tissues. Its greatest concentration, however, is in heart muscle, skeletal muscle, brain, liver and kidney, in decreasing order.1 We have already shown that, when measured in serum, this enzyme is elevated after acute myocardial infarction.2 This finding led us to study its concentration in liver diseases, since the enzyme is present in relatively high concentration in liver.

Glutamic oxalacetic transaminase is present in all human sera and will henceforth be referred to as SGO-T. Comparable concentrations are found whether chromatographic or spectrophotometric methods are employed.3 When serum is added to excesses

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WRÓBLEWSKI F, LADUE JS. SERUM GLUTAMIC OXALACETIC TRANSAMINASE ACTIVITY AS AN INDEX OF LIVER CELL INJURY: A PRELIMINARY REPORT*†. Ann Intern Med. 1955;43:345–360. doi: https://doi.org/10.7326/0003-4819-43-2-345

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Published: Ann Intern Med. 1955;43(2):345-360.

DOI: 10.7326/0003-4819-43-2-345

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