ESTHER FINCHER HAYS, M.D.; RALPH L. ENGLE JR., M.D.
Recent studies have shown that sickle hemoglobin can be differentiated electrophoretically from normal adult hemoglobin,1, 2 and have also demonstrated the existence of a new abnormal hemoglobin, which has been designated as hemoglobin C.3, 4 It has been shown further that hemoglobin C, like sickle cell hemoglobin, is a hereditary abnormality. Its inheritance is as a Mendelian dominant. Homozygous hemoglobin C produces a mild hemolytic anemia and an increase in target cells in the peripheral blood. Cases have been described by Spaet, Alway and Ward,9 Ranney, Larsen and McCormack,6 and Watson.10 The trait for hemoglobin C produces no symptoms. All
HAYS EF, ENGLE RL. SICKLE CELL-HEMOGLOBIN C DISEASE*. Ann Intern Med. 1955;43:412–418. doi: https://doi.org/10.7326/0003-4819-43-2-412
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Published: Ann Intern Med. 1955;43(2):412-418.
Hematology/Oncology, Red Cell Disorders.
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