JOHN A. LUETSCHER JR.; ROBERT H. CURTIS
Accumulation of edema and serous effusions occurs in different clinical patterns, depending on the basic pathology. Changes in capillary pressure or colloid osmotic pressure lead to increase of interstitial fluid at the expense of plasma volume. This process alone would lead to vascular collapse rather than to edema. Retention of ingested sodium and water provides the bulk of edema and may be a useful compensation against falling plasma volume. Sodium retention may be associated with impaired renal blood flow or glomerular filtration, but in most patients the renal tubule appears to exert final control of sodium excretion. The work presented
LUETSCHER JA, CURTIS RH. ALDOSTERONE: OBSERVATIONS ON THE REGULATION OF SODIUM AND POTASSIUM BALANCE*†. Ann Intern Med. 1955;43:658–666. doi: https://doi.org/10.7326/0003-4819-43-4-658
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Published: Ann Intern Med. 1955;43(4):658-666.
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Nephrology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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