WESLEY W. SPINK, M.D., F.A.C.P.
In their initial reports upon the effects of corticotropin and cortisone in patients having rheumatoid arthritis or rheumatic fever, Hench and his associates1, 2 emphasized two manifestations: inflammation of the tissues was subdued, and the patients experienced a remarkable sense of well-being. Soon thereafter, extensive observations were made by others3, 4, 5 in human subjects having a variety of infections, and in experimentally infected animals. It was demonstrated in patients with pneumococcal pneumonia that the administration of ACTH caused a crisis and striking improvement, although pneumococci persisted in the tissues for many days.6 On the other hand, it was also
SPINK WW. ADRENOCORTICOTROPIC HORMONE AND ADRENAL STEROIDS IN THE MANAGEMENT OF INFECTIOUS DISEASES*. Ann Intern Med. 1955;43:685–701. doi: https://doi.org/10.7326/0003-4819-43-4-685
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Published: Ann Intern Med. 1955;43(4):685-701.
Adrenal Disorders, Endocrine and Metabolism, Infectious Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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