HERBERT A. PERKINS, M.D.; J. M. BOULWARE, M.D.; T. V. FEICHTMEIR, M.D.; WILLIAM W. THAYER, M.D.; THEODORE H. SPAET, M.D.
Paroxysmal nocturnal hemoglobinuria (PNH) is a chronic hemolytic anemia characterized clinically by hemoglobinuria, exacerbation of the hemolytic process during sleep, leukopenia, thrombocytopenia, and a marked tendency to spontaneous thrombosis. The hemolysis has been demonstrated to be due to an acquired defect of the red blood cells, the cause of this defect being completely unknown. These defective cells are abnormally susceptible to hemolysis in their own or homologous normal serum.
Considerable work has been done in an effort to elucidate the mechanism of the hemolytic system. Ham and others, working in the late 1930's demonstrated that PNH red cells are readily
PERKINS HA, BOULWARE JM, FEICHTMEIR TV, et al. PAROXYSMAL NOCTURNAL HEMOGLOBINURIA: REPORT OF FOUR CASES, WITH OBSERVATIONS ON TREATMENT WITH 3,3′-METHYLENEBIS (4-HYDROXYCOUMARIN) (DICUMAROL)*. Ann Intern Med. 1955;43:1218–1229. doi: https://doi.org/10.7326/0003-4819-43-6-1218
Download citation file:
Published: Ann Intern Med. 1955;43(6):1218-1229.
Hematology/Oncology, Red Cell Disorders.
Results provided by:
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use