HAROLD L. ISRAEL, M.D., F.A.C.P.; MAURICE SONES, M.D., F.A.C.P.
Before considering whether a specific diagnostic test for sarcoidosis is available, it is appropriate for us to inquire whether sarcoidosis is a specific disease. Some writers have questioned whether there is such an entity, and have suggested that sarcoidosis is merely a type of histologic response which may be produced by a wide variety of etiologic agents.1 This point of view has merit: it is worthy of repeated emphasis that many agents—bacterial, viral, fungal, protozoan and mineral—can produce tuberculoid tissue changes which may be designated as the sarcoid reaction.2 There is, however, persuasive epidemiologic3, 4 and clinical5, 6 evidence that
ISRAEL HL, SONES M. THE DIAGNOSIS OF SARCOIDOSIS WITH SPECIAL REFERENCE TO THE KVEIM REACTION*†. Ann Intern Med. 1955;43:1269–1282. doi: https://doi.org/10.7326/0003-4819-43-6-1269
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Published: Ann Intern Med. 1955;43(6):1269-1282.
Infectious Disease, Mycobacterial Infections.
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