EDWARD I. CHERNISS, M.D.; BURTON A. WAISBREN, M.S., M.D.
North American blastomycosis is recognized as a chronic granulomatous infection caused by the hyphomycete, Blastomyces dermatitidis. It appears in man both as a relatively benign dermatologic infection and as a malignant, widely disseminated systemic disease that has predilection for lungs, bones and subcutaneous tissue. The cutaneous form has been successfully treated with iodides, radiation and excision.1 The systemic form has been notoriously resistant to therapy and associated with a high mortality.2 Both types have been characterized by chronicity and periods of indolence and exacerbation, with recurrence after prolonged periods of clinical inactivity or cure.2, 3 Fulminant, rapidly fatal pulmonary
CHERNISS EI, WAISBREN BA. NORTH AMERICAN BLASTOMYCOSIS: A CLINICAL STUDY OF 40 CASES*. Ann Intern Med. 1956;44:105–123. doi: https://doi.org/10.7326/0003-4819-44-1-105
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Published: Ann Intern Med. 1956;44(1):105-123.
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