ROYAL ROTTER; WILLIAM F. LUTTGENS; WESLEY L. PETERSON; ALBERT E. STOCK; ARNO G. MOTULSKY, M.D.
Evidence has accumulated that individuals with sicklemia, when exposed to decreased oxygen tension during airplane flight, may develop infarction of the spleen. In 1950 Sullivan1 described one case of sickle cell trait with sudden splenic enlargement following an airplane flight. Since that time several reports from military establishments have appeared in the literature which have confirmed the association of splenic infarction, sicklemia and airplane flight. Cooley, Peterson, Engel and Jernigan2 reported six cases of massive splenic infarction in Negroes following air travel. Each individual was treated with splenectomy. Two more cases of splenic infarction in Negroes precipitated by aerial flight
ROTTER R, LUTTGENS WF, PETERSON WL, et al. SPLENIC INFARCTION IN SICKLEMIA DURING AIRPLANE FLIGHT: PATHOGENESIS, HEMOGLOBIN ANALYSIS AND CLINICAL FEATURES OF SIX CASES*†. Ann Intern Med. 1956;44:257–270. doi: https://doi.org/10.7326/0003-4819-44-2-257
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Published: Ann Intern Med. 1956;44(2):257-270.
Hematology/Oncology, Red Cell Disorders.
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