WILLIAM B. SCHARFMAN, M.D.; SIMON PROPP, M.D., F.A.C.P.
This report is concerned with a severe hemorrhagic disease which followed prolonged diarrhea. The patient presented as a medical emergency which was promptly relieved by appropriate therapy. Subsequent investigation established the diagnosis of sprue which had caused severe hypoprothrombinemia.
Several clinical features of this case deserve emphasis. The hypoprothrombinemia was so extreme as to endanger the patient's life. Further, the immediate medical problem was not characteristic of sprue, but was due to a rare complication of the abnormal physiology of this disease. The infrequency of severe purpura associated with diarrhea probably accounted for the delay in diagnosis. The importance of
SCHARFMAN WB, PROPP S. PROLONGED DIARRHEA WITH NEAR-FATAL HEMORRHAGE DUE TO HYPOPROTHROMBINEMIA*. Ann Intern Med. 1956;44:385–391. doi: https://doi.org/10.7326/0003-4819-44-2-385
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Published: Ann Intern Med. 1956;44(2):385-391.
Coagulopathies, Diarrhea, Gastroenterology/Hepatology, Hematology/Oncology.
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