E. D. THOMAS
Since Waltner and Waltner1 first discovered that cobalt produces polycythemia in animals, physicians have attempted to employ this element in the therapy of anemia. One group of anemias that has attracted particular attention is that of the refractory anemias. Most investigators have found cobalt to have no therapeutic value in this type of anemia. Berk, Burchenal and Castle2 treated five patients with refractory anemia and hypercellular marrow with 300 mg. of cobaltous chloride daily with no reticulocyte response or rise in blood values. Weissbecker3 found cobalt to be of no value in six cases of aplastic anemia.
However, a few
THOMAS ED. THE TREATMENT OF REFRACTORY ANEMIA WITH COBALT*†. Ann Intern Med. 1956;44:412–419. doi: https://doi.org/10.7326/0003-4819-44-2-412
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Published: Ann Intern Med. 1956;44(2):412-419.
Hematology/Oncology, Red Cell Disorders.
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