RICHARD E. LEE; ARTHUR M. SELIGMANN; DAVID GOEBEL; LYMAN A. FULTON; MELVA A. CLARK
Although mild and labile hypertension frequently responds to Rauwolfia and its derivatives,1, 2, 3 more advanced hypertensive disease usually requires an additional pharmacologic agent.4, 5, 6, 7, 8 Hydralazine has proved a useful supplementary drug in many such cases. At the dosage levels employed, however, "toxic" side effects have appeared in many instances.9, 10 As many as 12% or more of patients receiving over 300 mg. of hydralazine daily may develop arthralgia and/or a "lupus-like" syndrome.10 Other instances of toxicity reported in the literature and presented in summary form in table 1 suggest that high dosage level may be an
LEE RE, SELIGMANN AM, GOEBEL D, FULTON LA, CLARK MA. RESERPINE-HYDRALAZINE COMBINATION THERAPY OF HYPERTENSIVE DISEASE, WITH HYDRALAZINE IN DOSES GENERALLY BELOW THE "TOXIC RANGE"12. Ann Intern Med. 1956;44:456–465. doi: 10.7326/0003-4819-44-3-456
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Published: Ann Intern Med. 1956;44(3):456-465.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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