ALVAN R. FEINSTEIN, M.D.; ROBERT G. PETERSDORF, M.D.
In certain diseases the occurrence of hyperglobulinemia has been noted so frequently that the laboratory finding of an elevated serum globulin, without evident clinical explanation, will usually provoke an intensive diagnostic search for evidence of their presence. Among the conditions regularly associated with hyperglobulinemia are multiple myeloma, sarcoidosis, collagen disease, cirrhosis of the liver, kala-azar, lymphogranuloma venereum and certain other infections. The first three of these diseases in particular may often be unsuspected following routine clinical examinations, and are found only after the discovery of hyperglobulinemia gives the first clue leading to the diagnosis.
At many hospitals the quantitative measurement
FEINSTEIN AR, PETERSDORF RG. THE CLINICAL SIGNIFICANCE OF HYPERGLOBULINEMIA. I. DIAGNOSTIC IMPLICATIONS*. Ann Intern Med. 1956;44:899–924. doi: https://doi.org/10.7326/0003-4819-44-5-899
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Published: Ann Intern Med. 1956;44(5):899-924.
Hematology/Oncology, Multiple Myeloma.
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