S. C. FREED, M.D.; J. W. KEATING, B.S.; E. E. HAYS, Ph.D.
There has been an increasing acceptance of therapeutic preparations designed to produce a prolonged effect after oral (or parenteral) administration. The long-acting oral preparations have the advantage of convenience and a more uniform and consistent action. This is especially desirable for drugs used to suppress appetite in the treatment of obesity.
Most long-acting appetite-suppression products now available depend upon the principle of the dissolution of variously sized, enteric-coated granules making their respective drug loads available at different times. Experience has proved that such a means of delaying the release of drugs varies considerably from individual to individual, and from
FREED SC, KEATING JW, HAYS EE. AMPHETAMINE-RESIN COMPLEX FOR PROLONGED APPETITE SUPPRESSION*. Ann Intern Med. 1956;44:1136–1141. doi: https://doi.org/10.7326/0003-4819-44-6-1136
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Published: Ann Intern Med. 1956;44(6):1136-1141.
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