STUART W. COSGRIFF, M.D.
Anticoagulant therapy with the coumarin and indandione derivatives has been made less hazardous by the demonstration that Vitamin K1 and Vitamin K1 oxide1-5 produce a prompt reversal of excessive hypoprothrombinemia. Intravenous Vitamin K1 in dosage varying from 50 to 500 mg. of the oil-soluble emulsion will effect the prompt return of an elevated prothrombin time approximately to normal within 12 hours in most patients, frequently accompanied by cessation of bleeding when a hemorrhagic complication is present.
The emulsion of Vitamin K1, originally prepared for intravenous administration, has been reported also to be effective by mouth.6-9 Hanson7 found that the prothrombin
COSGRIFF SW. THE EFFECTIVENESS OF AN ORAL VITAMIN K1 IN CONTROLLING EXCESSIVE HYPOPROTHROMBINEMIA DURING ANTICOAGULANT THERAPY*. Ann Intern Med. 1956;45:14–22. doi: https://doi.org/10.7326/0003-4819-45-1-14
Download citation file:
Published: Ann Intern Med. 1956;45(1):14-22.
Results provided by:
Copyright © 2020 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use