FRANCIS C. LOWELL, M.D., F.A.C.P.; WILLIAM FRANKLIN, M.D.; ALAN L. MICHELSON, M.D.; IRVING W. SCHILLER, M.D.
During the last two years a number of patients with chronic obstructive emphysema have been observed while under treatment with bronchodilator agents and the adrenal steroids, in the course of which our attention was drawn to an association between pulmonary emphysema, peptic ulcer, carcinoma of the lung and a high incidence of smoking. The association between emphysema and smoking was so striking that we postulated that smoking is the major factor in the pathogenesis of emphysema in this area.1 The present report is a detailed analysis of the data on which this opinion was based.
It was only after we
LOWELL FC, FRANKLIN W, MICHELSON AL, et al. CHRONIC OBSTRUCTIVE PULMONARY EMPHYSEMA: A DISEASE OF SMOKERS1. Ann Intern Med. 1956;45:268–274. doi: 10.7326/0003-4819-45-2-268
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Published: Ann Intern Med. 1956;45(2):268-274.
Cardiology, Chronic Obstructive Airway Disease, Coronary Risk Factors, Pulmonary/Critical Care, Smoking.
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