JAMES H. JANDL, M.D.; ARNOLD A. LEAR, M.D.
The prevalence of macrocytic anemia in patients with chronic liver disease has suggested to many observers that liver damage disturbs hematopoiesis by altering the storage or the metabolism of one or more of the substances effective in the treatment of pernicious anemia.1-4 However, it has been observed that most cases of the macrocytic anemia of liver disease bear little resemblance to pernicious anemia morphologically, and generally do not respond to liver extract.5, 6 Moreover, extracts prepared from the livers of patients with the anemia of liver disease have been found to possess antipernicious anemia activity.7 Nevertheless, apparent hematologic responses to
JANDL JH, LEAR AA. THE METABOLISM OF FOLIC ACID IN CIRRHOSIS*. Ann Intern Med. 1956;45:1027–1044. doi: https://doi.org/10.7326/0003-4819-45-6-1027
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Published: Ann Intern Med. 1956;45(6):1027-1044.
Gastroenterology/Hepatology, Liver Disease.
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