RICHARD CHARET, M.D., F.A.C.P.; BERNARD BRILL, M.D.; CIPRIANO ELLOSO, M.D.
The anxiety states are so common that new sedative drugs are constantly being sought. Recently, the propanediol derivatives seemed to be among the most promising. The newest compound of this type is meprobamate (Miltown) (2-methyl-2-N-propyl-1,3-propanediol dicarbamate). The chemical was first synthesized in 1950 by Ludwig and Piech.1 The pharmacology was first described by Berger.2, 3 He demonstrated that it produces muscle relaxation and sedation through its action on the central nervous system by its inhibiting effect on the internuncial circuits. It is considered a practical, safe and clinically useful central nervous system depressant.
Borrus4 treated 67 patients with no ill
CHARET R, BRILL B, ELLOSO C. COMA AFTER MILTOWN OVERDOSE1. Ann Intern Med. 1956;45:1211–1213. doi: 10.7326/0003-4819-45-6-1211
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Published: Ann Intern Med. 1956;45(6):1211-1213.
Emergency Medicine, Neurology.
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