MANUEL SKLAR, M.D.; JOSEPH B. KIRSNER, M.D., F.A.C.P.; WALTER L. PALMER, M.D., F.A.C.P.
Ulcerative colitis is a serious disabling disease of variable course, with remissions and exacerbations at unpredictable intervals. Prior to adrenal corticotherapy, conventional medical management, although helpful in the majority of the patients, seldom produced dramatic results. In a series1 of 100 cases reported in 1948, 53 patients were estimated to have benefited from medical therapy. Fourteen patients died; the most common cause of death (nine patients) was peritonitis secondary to perforation of the bowel. In a recent survey2 of 180 cases treated with ACTH, cortisone, hydrocortisone and related compounds in the years 1950 through 1955, a satisfactory, often very
SKLAR M, KIRSNER JB, PALMER WL. PROBLEMS IN THE MANAGEMENT OF ULCERATIVE COLITIS, WITH PARTICULAR REFERENCE TO ACTH AND THE ADRENAL STEROIDS*. Ann Intern Med. 1957;46:1–20. doi: https://doi.org/10.7326/0003-4819-46-1-1
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Published: Ann Intern Med. 1957;46(1):1-20.
Adrenal Disorders, Endocrine and Metabolism, Gastroenterology/Hepatology, Inflammatory Bowel Disease.
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