LEROY K. BRANCH, M.D.; SANFORD W. TUTHILL, M.D.
These cases warrant comment since no report has appeared in which twins were born with goiters iatrogenically produced with propylthiouracil and iodine. No clinical evidence of hypothyroidism appeared in the infants.
A three months pregnant, 41 year old white female had complained of increasing nervousness, severe palpitation, easier fatigue, weakness and increased sweating for several months. There was no history of diarrhea, heat intolerance, insomnia or previous symptoms to suggest thyroid dysfunction. Examination revealed an apprehensive patient with a resting pulse rate of 138 beats per minute. After one hour's rest the pulse rate was 120. A mild
BRANCH LK, TUTHILL SW. GOITERS IN TWINS RESULTING FROM PROPYLTHIOURACIL GIVEN DURING PREGNANCY1. Ann Intern Med. ;46:145–148. doi: 10.7326/0003-4819-46-1-145
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Published: Ann Intern Med. 1957;46(1):145-148.
Endocrine and Metabolism, Thyroid Disorders.
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