ALVIN J. CUMMINS, M.D.
"Antispasmodic" drugs, as applied to the gastrointestinal tract, are of two varieties: (a) those depressing smooth muscle activity directly, and (b) those acting through inhibition of the parasympathetic nervous system. The first type, as exemplified by papaverine and the nitrites, has rather evanescent effects on muscle activity and, because of lack of effect on gastric secretory function, has found relatively little application in gastroenterologic therapeutics outside of acute exhibition in cases involving spasm of the biliary system. The second type of drug action can be effected either through depression of the central nervous system, blockade of peripheral ganglionic transmission or
CUMMINS AJ. USE AND ABUSE OF ANTICHOLINERGIC DRUGS IN THE MANAGEMENT OF GASTROINTESTINAL DISEASE1. Ann Intern Med. 1957;46:352–359. doi: 10.7326/0003-4819-46-2-352
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Published: Ann Intern Med. 1957;46(2):352-359.
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