JOHN F. MURRAY, M.D.; S. FRED RABINER, M.D.; BERNARD KABAKOW, M.D.
Cortisone, hydrocortisone, and adrencorticotropic hormone (ACTH) have been employed therapeutically in a variety of blood dyscrasias.1 These compounds have been found particularly effective in thrombocytopenic purpura,2 acquired hemolytic anemias3 and, to a lesser extent, in acute leukemias.4 Recently several reports have suggested that cortisone and ACTH are useful, and may perhaps be life-saving, in the treatment of drug-induced agranulocytosis.5-9
The following is a report of a patient with marked bone marrow depression, possibly secondary to propylthiouracil administration, who showed an initial response to intravenous hydrocortisone and was subsequently successfully treated with ACTH.
A 36 year old white unmarried
MURRAY JF, RABINER SF, KABAKOW B. BONE MARROW DEPRESSION SUCCESSFULLY TREATED WITH HYDROCORTISONE AND CORTICOTROPIN (ACTH)1. Ann Intern Med. ;46:387–391. doi: 10.7326/0003-4819-46-2-387
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Published: Ann Intern Med. 1957;46(2):387-391.
Hematology/Oncology, Hospital Medicine.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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