D. W. JOHNSTON, M.D.
Diffuse osteosclerosis is of varied etiology. Its pathogenesis is poorly understood. The clinical and x-ray features have become stereotyped in most cases, but do not as a rule suggest the etiology.
The conditions in which osteosclerosis, with or without hyperostosis, is seen, are:
2. Postoperative hyperparathyroidism.
3. Neoplasia, especially carcinoma of the prostate.
4. Hypervitaminosis D and, more rarely, A.
6. Phosphorus poisoning.
The known causes of overgrowth of periosteal bone are:
2. Healed scurvy.
3. Healed rickets.
The primary disorders of unknown etiology which cause increased density of bone are:
JOHNSTON DW. GENERALIZED OSTEOSCLEROSIS ASSOCIATED WITH DIABETES INSIPIDUS AND NEUROLOGIC SYMPTOMS*. Ann Intern Med. 1957;46:619–628. doi: https://doi.org/10.7326/0003-4819-46-3-619
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Published: Ann Intern Med. 1957;46(3):619-628.
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