ROBERT E. BOLINGER, M.D., F.A.C.P.; MAHLON H. DELP, M.D., F.A.C.P.
Since the original descriptions of Cushing's disease as a form of pituitary basophilism,1, 2 the emphasis has gradually shifted so that the adrenal cortex is now known to be essential for the genesis of the syndrome.3, 4, 5 The exact role which the pituitary or the hypothalamus6, 7 may play is in some doubt, and therapeutic approaches directed at other than the adrenal cortex, such as pituitary irradiation2 and androgens,8, 9 have been disappointing. Satisfactory remissions after surgical resection of the adrenal glands have, however, been reported by Collett,10 Walters et al.,4 Walters and Kepler,11 Walters12 and Cope and Raker.13
BOLINGER RE, DELP MH. MEDICAL CONSIDERATIONS IN ADRENAL SURGERY1. Ann Intern Med. ;46:662–677. doi: 10.7326/0003-4819-46-4-662
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Published: Ann Intern Med. 1957;46(4):662-677.
Adrenal Disorders, Endocrine and Metabolism.
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