JOHN COLLINS HARVEY, M.D.; JAMES R. CANTRELL, M.D.; A. MURRAY FISHER, M.D.
Although many of the strains of Actinomyces are highly sensitive in vitro to many antimicrobial agents, the disease caused in human beings by these microörganisms continues to present difficult therapeutic problems. The distinctive character of the tissue reaction offers a logical explanation for some of these problems. The involved areas are usually extensive, markedly indurated, and relatively avascular in the region of the active growth of the Actinomyces. These features suggest serious difficulty in getting a bactericidal concentration of the effective drug into areas of active infection, and raise serious doubts concerning the possibility of restoring the involved tissues
HARVEY JC, CANTRELL JR, FISHER AM. ACTINOMYCOSIS: ITS RECOGNITION AND TREATMENT1. Ann Intern Med. 1957;46:868–885. doi: 10.7326/0003-4819-46-5-868
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Published: Ann Intern Med. 1957;46(5):868-885.
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