GEORGE L. BERO, M.D.
Amyloidosis is a generalized disease characterized by the deposition of a homogeneous substance in the media of arteries and perivascular connective tissues. Because of its starchlike staining with iodine, Virchow (1853) considered the substance a carbohydrate moiety, and originated the term "amyloid." The chemical nature of amyloid has never been clearly elucidated, but the studies of Eppinger (1922) and Hass (1940)21 demonstrated the presence of both protein and polysaccharide elements. It is not known whether the substance is produced locally or transported to the site of deposition, nor is it known whether it is an abnormal substance, or a normal
BERO GL. AMYLOIDOSIS: ITS CLINICAL AND PATHOLOGIC MANIFESTATIONS, WITH A REPORT OF 12 CASES1. Ann Intern Med. 1957;46:931–955. doi: 10.7326/0003-4819-46-5-931
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Published: Ann Intern Med. 1957;46(5):931-955.
Endocrine and Metabolism, Hematology/Oncology, Hospital Medicine, Infectious Disease, Leukemia/Lymphoma.
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