TOM P. HAYNIE, M.D.; HAROLD L. DOBSON, M.D.; ROBERT A. HETTIG, M.D.
The discovery by Pauling, Itano, Singer and Wells1 that normal and sickle cell hemoglobins have different electrophoretic mobilities provoked a great amount of thought and investigation concerning the molecular aberrations of hemoglobin. To the clinician as well as to the medical investigator, this discovery crystallized the concept that a molecular abnormality in a single substance might cause a sequence of events productive of serious disease states. For the clinical hematologist and the geneticist, the study of abnormal hemoglobins has provided a method of classifying inherited hemoglobin disorders which no other approach has equaled in simplicity and accuracy.
HAYNIE TP, DOBSON HL, HETTIG RA. MOLECULAR DISEASES OF HEMOGLOBIN. I. INTRODUCTION AND INCIDENCE*. Ann Intern Med. 1957;46:1031–1038. doi: https://doi.org/10.7326/0003-4819-46-6-1031
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Published: Ann Intern Med. 1957;46(6):1031-1038.
Hematology/Oncology, Hospital Medicine, Red Cell Disorders.
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