TOM P. HAYNIE, M.D.; HAROLD L. DOBSON, M.D.; ROBERT A. HETTIG, M.D.
The discovery by Pauling, Itano, Singer and Wells1 that normal and sickle cell hemoglobins have different electrophoretic mobilities provoked a great amount of thought and investigation concerning the molecular aberrations of hemoglobin. To the clinician as well as to the medical investigator, this discovery crystallized the concept that a molecular abnormality in a single substance might cause a sequence of events productive of serious disease states. For the clinical hematologist and the geneticist, the study of abnormal hemoglobins has provided a method of classifying inherited hemoglobin disorders which no other approach has equaled in simplicity and accuracy.
HAYNIE TP, DOBSON HL, HETTIG RA. MOLECULAR DISEASES OF HEMOGLOBIN. I. INTRODUCTION AND INCIDENCE1. Ann Intern Med. 1957;46:1031–1038. doi: 10.7326/0003-4819-46-6-1031
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Published: Ann Intern Med. 1957;46(6):1031-1038.
Hematology/Oncology, Hospital Medicine, Red Cell Disorders.
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