MORGAN CUTTS, M.D., F.A.C.P.
The occurrence of jaundice following chlorpromazine therapy has been repeatedly noted, but the exact mechanism of its production remains in doubt.1, 2 Some authors suggest a drug sensitivity, others an increased viscosity of the bile produced by the medication. Recently, benefit from treatment with cortisone in one case has been reported.1 Following is a report of another such case.
A 45 year old woman was admitted to the hospital because of increasing anorexia, nausea, weakness and epigastric distress for 10 days. For one week she had noted increasingly dark urine and severe generalized pruritus. She had taken 25
CUTTS M. CHLORPROMAZINE HEPATITIS TREATED WITH CORTISONE1. Ann Intern Med. ;46:1160–1161. doi: 10.7326/0003-4819-46-6-1160
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Published: Ann Intern Med. 1957;46(6):1160-1161.
Gastroenterology/Hepatology, Liver Disease.
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