THEODORE BACHARACH; JOSEPH R. EVANS
Constipation, flatulence and mild distention are well known clinical findings associated with myxedema.1, 2 Medical texts and monographs on gastrointestinal disease make rare mention of the association of hypothyroidism and a megacolon-like syndrome manifest by actual enlargement of the colon. Megacolon on this basis has only infrequently been reported in the medical literature.3, 4
Pathologic studies of the bowel wall have been reported as showing the following changes:3 The wall of the colon is thickened and somewhat whitish, with a loss of elasticity and the consistency of soft leather; on microscopic examination, the lesions are characterized by a myxedematous infiltration
BACHARACH T, EVANS JR. ENLARGEMENT OF THE COLON SECONDARY TO HYPOTHYROIDISM*. Ann Intern Med. 1957;47:121–124. doi: https://doi.org/10.7326/0003-4819-47-1-121
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Published: Ann Intern Med. 1957;47(1):121-124.
Endocrine and Metabolism, Gastroenterology/Hepatology, Thyroid Disorders.
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