WILLIAM R. KAY, M.D., F.A.C.P.; HENRY G. KUPFER, M.D.
Hemorrhage, either spontaneous or following trauma, is the essential symptom of hemophilia. Joints are commonly involved, and epistaxis, bleeding following dental extractions, hematuria, bleeding from the gastrointestinal tract, and subcutaneous and intramuscular hemorrhages are frequently observed. Pulmonary and subpleural shadows thought to represent hemorrhage have been reported,1 but massive spontaneous bleeding into the pleural space as a manifestation of hemophilia is quite unusual.2
True spontaneous hemothorax is to be differentiated from spontaneous pneumohemothorax. Most of the cases reported in the literature as spontaneous hemothorax have actually been cases of pneumohemothorax.3 This latter condition is usually ascribed to the rupture of
KAY WR, KUPFER HG. SPONTANEOUS HEMOTHORAX IN HEMOPHILIA: CASE REPORT AND DISCUSSION OF THE HEMOPHILIA SYNDROMES, WITH REMARKS ON THE MANAGEMENT OF HEMOTHORAX1. Ann Intern Med. 1957;47:152–161. doi: 10.7326/0003-4819-47-1-152
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Published: Ann Intern Med. 1957;47(1):152-161.
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