GEORGE B. JERZY GLASS, M.D., F.A.C.P.; LINN J. BOYD, M.D., F.A.C.P.
The differential diagnosis of various types of macrocytic anemia often presents difficult clinical problems. Many cases of dietary folic acid or B12 deficiency and sprue cannot be distinguished from pernicious anemia by any available criterion. Moreover, very often pernicious anemia in remission or in a nonanemic stage, and the oligosymptomatic sprue, can be diagnosed only tentatively by history, since the clinical and hematologic findings following treatment, including B12 levels in blood, may be uninformative.
In all these instances the determination of the presence or absence of Castle's intrinsic factor in the stomach has diagnostic significance, since its secretion is abolished
JERZY GLASS GB, BOYD LJ. DIFFERENTIATION OF MACROCYTIC ANEMIAS AND DIAGNOSIS OF PERNICIOUS ANEMIA AND SPRUE IN REMISSION BY ACCELERATED MEASUREMENT OF HEPATIC UPTAKE OF RADIOACTIVE Co60B12*. Ann Intern Med. 1957;47:274–292. doi: https://doi.org/10.7326/0003-4819-47-2-274
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Published: Ann Intern Med. 1957;47(2):274-292.
Celiac Disease and Malabsorption, Gastroenterology/Hepatology, Hematology/Oncology, Red Cell Disorders.
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