TIMOTHY R. TALBOT JR., M.D.; ALBERT F. TETREAULT, M.D.
Pernicious anemia is due to the absence of intrinsic factor in the patient's gastric secretions, leading to an inability to absorb vitamin B12 present in the diet.1 We have recently observed two patients in whom all of the classic criteria for severe pernicious anemia were present, but in whom a normal ability to absorb vitamin B12 from the gastrointestinal tract was demonstrated by means of the absorption test employing cobalt60-labeled vitamin B12.2
Both patients demonstrated the following symptoms and signs: glossitis, diarrhea, vomiting, mental disturbances, generalized progressive weakness, severe macrocytic anemia, thrombocytopenia, moderate leukopenia with hypersegmented polymorphonuclear leukocytes, a megaloblastic
TALBOT TR, TETREAULT AF. PROBABLE DEFICIENCY OF VITAMIN B12 WITH "PERNICIOUS ANEMIA" IN TWO PATIENTS WITH NORMAL SCHILLING TEST1. Ann Intern Med. ;47:338–346. doi: 10.7326/0003-4819-47-2-338
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Published: Ann Intern Med. 1957;47(2):338-346.
Hematology/Oncology, Red Cell Disorders.
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