RYLE A. RADKE; WADDY G. BAROODY
Inorganic arsenic has been employed empirically in therapeutics for centuries. Modern use of the drug dates from the researches of Paul Ehrlich into syphilotherapy, during which time he synthesized and tested the treponemicidal effect of organic arsenicals, including stovarsol and carbarsone. Marchoux1 demonstrated stovarsol to be amebicidal. Carbarsone (4-car-baminophenyl-arsonic acid) was shown to be amebicidal by Reed,2 since which time it has been employed extensively in antiamebic therapy. Reports of toxicity to this compound have been remarkably few, in sharp contrast to inorganic arsenic and the organic compounds formerly widely employed in syphilotherapy.
In reviewing the literature of carbarsone toxicity
RADKE RA, BAROODY WG. CARBARSONE TOXICITY: A REVIEW OF THE LITERATURE AND REPORT OF 45 CASES1. Ann Intern Med. ;47:418–427. doi: 10.7326/0003-4819-47-3-418
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Published: Ann Intern Med. 1957;47(3):418-427.
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