DONALD S. DOCK, M.D.; LUCIEN B. GUZE, M.D.
Subacute bacterial endocarditis has occurred in patients with valvular heart disease following operative procedures within the oral cavity despite the use of penicillin to prevent the transient bacteremia which may occur in such situations.1-4 In addition, bacterial endocarditis has been noted in patients receiving prophylactic penicillin against recurrent beta-hemolytic streptococcal infection. Hunter has observed one such instance in a child receiving oral penicillin.5 Two additional cases appeared among a group of 145 subjects with a history of rheumatic fever who were receiving monthly injections of benzathine penicillin; the causative organisms were penicillin-sensitive Streptococcus viridans.6 One of these patients had
DOCK DS, GUZE LB. SUBACUTE BACTERIAL ENDOCARDITIS OCCURRING IN A PATIENT RECEIVING ORAL PENICILLIN AS PROPHYLAXIS AGAINST RHEUMATIC FEVER*. Ann Intern Med. 1957;47:577–581. doi: https://doi.org/10.7326/0003-4819-47-3-577
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Published: Ann Intern Med. 1957;47(3):577-581.
Cardiology, Endocarditis, Infectious Disease, Rheumatology, Streptococcal Infections.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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