PAUL W. CLOUGH
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Although acquired immunity has been extensively studied and much has been learned regarding the role of the protective substances in the blood, the factors concerned with natural (spontaneous) resistance to infection are poorly understood. Recent studies, particularly by Pillemer and his associates, have demonstrated and partly characterized a previously unrecognized constituent of the serum which seems to play an important role in the defense from infection and probably in other biochemical reactions as well.
This substance, termed properdin by Pillemer,1 was first recognized during a study of complement. In an attempt to isolate the third constituent of complement, C'3 according
CLOUGH PW. PROPERDIN. Ann Intern Med. 1957;47:599–604. doi: https://doi.org/10.7326/0003-4819-47-3-599
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Published: Ann Intern Med. 1957;47(3):599-604.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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