PETER STERNLIEB, B.S.; SYLVAN H. EISMAN, M.D.
Cinchophen (phenylcinchoninic acid) was first synthesized by Doebner and Giesecke in 1887 and was introduced into the therapeutic armamentarium by Weintraub in 1911 as a uricosuric agent in the treatment of gout, and has been prescribed for rheumatoid arthritis, rheumatic fever, headache, neuritis, etc. In the two or three decades after its introduction cinchophen was used extensively in both prescribed and patent medications, despite the fact that attention had been called as early as 1923 to its serious undesirable side-effects. In that year Worster-Drought21 reported a case of toxic hepatitis due to cinchophen administration. Up to 1948 approximately 230 such
STERNLIEB P, EISMAN SH. TOXIC HEPATITIS AND AGRANULOCYTOSIS DUE TO CINCHOPHEN*. Ann Intern Med. 1957;47:826–834. doi: https://doi.org/10.7326/0003-4819-47-4-826
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Published: Ann Intern Med. 1957;47(4):826-834.
Emergency Medicine, Gastroenterology/Hepatology, Liver Disease.
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