ALFRED P. SPIVACK, M.D.; JAY A. NADEL, M.D.; GEORGE M. EISENBERG, D.SC.
Since Zenker first reported a case of cryptococcal infection of man in 1861,23 review articles have shown an increasing number of reported cases.15, 16, 19 This is most probably due to a greater awareness of the disease and to improved laboratory diagnostic procedures. Cryptococcus neoformans is a yeastlike, nonsporulating, budding fungus characterized by the development of a wide capsule both in tissue and in culture. It is ovoid to spherical in shape, and 5 to 15 μ in diameter.11 The organism and its characteristic capsule can be demonstrated both in culture on Sabouraud's glucose medium and directly in spinal fluid
SPIVACK AP, NADEL JA, EISENBERG GM. CRYPTOCOCCUS RENAL INFECTION: REPORT OF A CASE1. Ann Intern Med. 1957;47:990–1002. doi: 10.7326/0003-4819-47-5-990
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Published: Ann Intern Med. 1957;47(5):990-1002.
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