JOHN E. MIDDLEBROOK, M.D.
Hypofibrinogenemia has been recognized more frequently in recent years. Congenital afibrinogenemia, a condition caused by a congenital defect in the enzyme system responsible for fibrinogen production, has been recognized for many years. Acquired afibrinogenemia has been observed as a complication of shock,1 severe liver damage associated with a septic abortion and bacteremia,2 pulmonary surgery,3 severe tissue damage,4 inadequate protein intake,5 thrombotic thrombocytopenic purpura,6 polycythemia,7 and the various complications of pregnancy, including abruptio placentae, intra-uterine death, and amniotic fluid embolism.8, 9, 10 Acquired hypofibrinogenemia has also been observed in association with various malignant growths, including carcinoma of the prostate,11, 12 pancreas13,
MIDDLEBROOK JE. HYPOFIBRINOGENEMIA WITHOUT FIBRINOLYSIS ASSOCIATED WITH A LYMPHOMA AND CONTROLLED AFTER TREATMENT WITH CORTISONE AND NITROGEN MUSTARD1. Ann Intern Med. 1957;47:1242–1251. doi: 10.7326/0003-4819-47-6-1242
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Published: Ann Intern Med. 1957;47(6):1242-1251.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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