E. OSBORNE COATES JR., M.D., F.A.C.P.; GEOFFREY L. BRINKMAN, M.D.; FRANCES E. NOE, M.D.
Hypoventilation of the lungs, leading to lowered arterial oxygen saturation, carbon dioxide retention and respiratory acidosis, has long been recognized as a prominent feature of diffuse obstructive emphysema. Less well appreciated is the fact that significant hypoventilation may occur in other conditions both with and without obvious evidence of pulmonary disease. Prompt recognition of this situation is essential, since further reduction of ventilation, such as may result from the use of narcotics, or injudicious treatment with oxygen, may produce serious consequences. In addition, mental symptoms, presumably related to carbon dioxide retention, may develop in these individuals. These are particularly important
COATES EO, BRINKMAN GL, NOE FE. HYPOVENTILATION SYNDROME: PHYSIOLOGIC STUDIES IN SELECTED CASES1. Ann Intern Med. 1958;48:50–59. doi: 10.7326/0003-4819-48-1-50
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Published: Ann Intern Med. 1958;48(1):50-59.
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